Scientist

Title - Experimental DMPK Scientist – Oncology

Location - DISC, Cambridge, UK

Duration - 12 months (interim)

IR35 Status - Inside

Introduction to Role

We are seeking an Experimental DMPK Scientist to join the Oncology DMPK Experimental Team on a 12 month assignment , based at the AstraZeneca Discovery Centre, Cambridge, UK . This role offers an exciting opportunity for a junior scientist with practical experience in bioanalysis and/or in vitro DMPK to contribute to discovery-stage drug development within a highly collaborative scientific environment. The successful candidate will support the generation and interpretation of high-quality experimental data to inform progression of compounds across oncology discovery projects.

Accountabilities

The Experimental DMPK Scientist will be responsible for conducting laboratory-based studies to support discovery DMPK activities, with a particular focus on bioanalysis and/or in vitro DMPK . The role will involve execution of established assays, preparation and analysis of biological samples, data evaluation, and accurate documentation of experimental work. The postholder will work closely with colleagues across DMPK and wider multidisciplinary project teams to ensure timely delivery of data that supports project decision-making. They will also contribute to assay optimisation, troubleshooting, and the continuous improvement of laboratory practices, while maintaining high standards of scientific quality, data integrity, compliance, and safety.

Essential Skills/Experience

• Degree qualification in a relevant scientific discipline such as chemistry, biochemistry, biology, pharmaceutical sciences, pharmacology, , or equivalent.
• Practical laboratory experience in bioanalysis and/or in vitro DMPK .
• Understanding of fundamental DMPK principles and their application in a drug discovery setting.
• Experience in handling and preparing biological samples for analysis.
• Ability to generate, review, and interpret experimental data accurately.
• Strong organisational skills, with the ability to manage workload effectively and deliver to agreed timelines.
• Good written and verbal communication skills.
• Ability to work independently as well as collaboratively within a team environment.
• Commitment to safe working practices and high standards of data quality and integrity.

Desirable Skills/Experience

• knowledge of, or an interest in developing knowledge of, the following core DMPK principles
• Experience with LC-MS/MS in support of quantitative bioanalysis.
• Familiarity with in vitro DMPK assays such as metabolic stability, microsomal or hepatocyte incubations, permeability, protein binding , or related approaches.
• Experience of sample preparation techniques including protein precipitation, liquid-liquid extraction , or solid-phase extraction .
• Understanding of how DMPK data contributes to compound optimisation and progression in small molecule drug discovery.
• Previous experience in a pharmaceutical, biotechnology, or CRO environment.
• Awareness of assay performance, troubleshooting, and laboratory workflow improvement.

Why AstraZeneca

At AstraZeneca, we are driven by science and committed to delivering meaningful outcomes for patients. This role provides an opportunity to develop experience within Oncology DMPK while contributing to cutting-edge discovery research in a collaborative and innovative environment. Based in Cambridge , you will be part of a vibrant scientific community at the AstraZeneca Discovery Centre , working alongside colleagues who are passionate about advancing new medicines.